Fundamental life science and pharmaceutical research are continually striving to provide physiologically relevant context for their biological studies.Zebrafish present an opportunity for high-content screening (HCS) to bring a true in vivo model system to screening studies.Zebrafish embryos and young larvae are an economical, human-relevant model
Botulinum neurotoxins (BoNTs) type A and type B are commonly used as biopharmaceutics for neurological diseases, uniquely allowing months-long paralysis of target muscles.Their exquisite neuronal specificity is conferred by a multistep process of binding, internalization, cytosolic escape and cleavage of the neuron-specific proteins, SNAP-25 and ve
The design of screening methods for Amla the detection of genetically modified organisms (GMOs) in food would improve the efficiency in their control.We report here a PCR amplification method combined with a sequence-specific electrochemical genosensor for the quantification of a DNA sequence characteristic of the 35S promoter derived from the caul
A surface plasmon resonance (SPR) sensor based on a hollow fiber (HF) is proposed to realize high analyte refractive index (RI) detection.The hole in the HF as a microfluidic channel for the analyte is filled with a silver wire to replace the metal coating.The sensitivity of the proposed SPR sensor with analyte RI from 1.47 to 1.51 is theoretically
Introduction.Ontologies as knowledgebases have been heavily applied in computational biological studies by implementing into ML models for purposes such as disease-gene associations identification.Method.We conduct a case study using gene ontology (GO) annotation data and three ML models to 6 Piece King Poster Bedroom replicate the prediction of au